Article | Proceedings of The 9th EUROSIM Congress on Modelling and Simulation, EUROSIM 2016, The 57th SIMS Conference on Simulation and Modelling SIMS 2016 | Modelling of Target-Controlled Infusion of Propofol for Depth-of-Anaesthesia Simulation in Matlab-Simulink Linköping University Electronic Press Conference Proceedings
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Title:
Modelling of Target-Controlled Infusion of Propofol for Depth-of-Anaesthesia Simulation in Matlab-Simulink
Author:
Gorazd Karer: Faculty of Electrical Engineering, University of Ljubljana, Slovenia
DOI:
10.3384/ecp1714249
Download:
Full text (pdf)
Year:
2018
Conference:
Proceedings of The 9th EUROSIM Congress on Modelling and Simulation, EUROSIM 2016, The 57th SIMS Conference on Simulation and Modelling SIMS 2016
Issue:
142
Article no.:
007
Pages:
49-54
No. of pages:
6
Publication type:
Abstract and Fulltext
Published:
2018-12-19
ISBN:
978-91-7685-399-3
Series:
Linköping Electronic Conference Proceedings
ISSN (print):
1650-3686
ISSN (online):
1650-3740
Publisher:
Linköping University Electronic Press, Linköpings universitet


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Total intravenous anaesthesia (TIVA) is an anaesthesiologic technique, where substances are injected intravenously. The anaesthesiologist adjusts the injection of intravenous anaesthetic agents regarding the depth of anaesthesia. In the paper, we present a model of an anaesthetic agent, namely propofol, in?uencing the depth of anaesthesia. The in?uence of propofol is linked to the concentration of the drug in the appropriate compartment. First, the modelling of pharmacokinetics of propofol is introduced. The 3-compartmental model and the effect-site model are presented, the relevant model parameters are given. Next, the model is veri?ed by comparing the simulation results to the data ?le that was recorded by the Orchestra Base Primea infusion workstation during a medical procedure, which lasted about 40 minutes. The simulation results are presented and the predictive quality of the model is evaluated. The presented model for Matlab-Simulink provides a basic tool for further researching the dynamics of anaesthetic depth. Despite the fact that more data must be obtained in order to properly validate the model, the presented model provides a basis for running simulations and testing various scenarios of propofol administration and is usable for developing and testing closed-loop control approaches for automatic control of depth of anaesthesia.

Keywords: target-controlled infusion, Propofol, depth-of-anaesthesia, Matlab-Simulink

Proceedings of The 9th EUROSIM Congress on Modelling and Simulation, EUROSIM 2016, The 57th SIMS Conference on Simulation and Modelling SIMS 2016

Author:
Gorazd Karer
Title:
Modelling of Target-Controlled Infusion of Propofol for Depth-of-Anaesthesia Simulation in Matlab-Simulink
DOI:
http://dx.doi.org/10.3384/ecp1714249
References:
No references available

Proceedings of The 9th EUROSIM Congress on Modelling and Simulation, EUROSIM 2016, The 57th SIMS Conference on Simulation and Modelling SIMS 2016

Author:
Gorazd Karer
Title:
Modelling of Target-Controlled Infusion of Propofol for Depth-of-Anaesthesia Simulation in Matlab-Simulink
DOI:
https://doi.org10.3384/ecp1714249
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Last updated: 2019-10-02