Article | Proceedings of The 9th EUROSIM Congress on Modelling and Simulation, EUROSIM 2016, The 57th SIMS Conference on Simulation and Modelling SIMS 2016 | Tuning of Physiological Controller Motifs Linköping University Electronic Press Conference Proceedings
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Title:
Tuning of Physiological Controller Motifs
Author:
Kristian Thorsen: Department of Electrical Engineering and Computer Science, University of Stavanger, Norway Geir B. Risvoll: Department of Electrical Engineering and Computer Science, University of Stavanger, Norway Daniel M. Tveit: Department of Electrical Engineering and Computer Science, University of Stavanger, Norway Peter Ruoff: Center for Organelle Research, University of Stavanger, Norway Tormod Drengstig: Department of Electrical Engineering and Computer Science, University of Stavanger, Norway
DOI:
10.3384/ecp1714231
Download:
Full text (pdf)
Year:
2018
Conference:
Proceedings of The 9th EUROSIM Congress on Modelling and Simulation, EUROSIM 2016, The 57th SIMS Conference on Simulation and Modelling SIMS 2016
Issue:
142
Article no.:
005
Pages:
31-37
No. of pages:
7
Publication type:
Abstract and Fulltext
Published:
2018-12-19
ISBN:
978-91-7685-399-3
Series:
Linköping Electronic Conference Proceedings
ISSN (print):
1650-3686
ISSN (online):
1650-3740
Publisher:
Linköping University Electronic Press, Linköpings universitet


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Genetic manipulation is increasingly used to ?ne tune organisms like bacteria and yeast for production of chemical compounds such as biofuels and pharmaceuticals. The process of creating the optimal organism is dif?cult as manipulation may destroy adaptation and compensation mechanisms that have been tuned by evolution to keep the organisms ?t. The continued progress in synthetic biology depends on our ability to understand, manipulate, and tune these mechanisms. Concepts from control theory and control engineering are very applicable to these challenges. From a control theoretic viewpoint, disturbances rejection and set point tracking describe how adaptation mechanisms relate to perturbations and to signaling events. In this paper we investigate a set regulatory mechanisms in the form of biochemical reaction schemes, so called controller motifs. We show how parameters related to the molecular and kinetic mechanisms in?uence on the dynamical behavior of disturbance rejection and set point tracking of each controller motif. This gives insight into how a molecular controller motif can be tuned to a speci?ed regulatory response.

Keywords: bioengineering, biological systems, adaptation

Proceedings of The 9th EUROSIM Congress on Modelling and Simulation, EUROSIM 2016, The 57th SIMS Conference on Simulation and Modelling SIMS 2016

Author:
Kristian Thorsen, Geir B. Risvoll, Daniel M. Tveit, Peter Ruoff, Tormod Drengstig
Title:
Tuning of Physiological Controller Motifs
DOI:
http://dx.doi.org/10.3384/ecp1714231
References:
No references available

Proceedings of The 9th EUROSIM Congress on Modelling and Simulation, EUROSIM 2016, The 57th SIMS Conference on Simulation and Modelling SIMS 2016

Author:
Kristian Thorsen, Geir B. Risvoll, Daniel M. Tveit, Peter Ruoff, Tormod Drengstig
Title:
Tuning of Physiological Controller Motifs
DOI:
https://doi.org10.3384/ecp1714231
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Citations:
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Last updated: 2019-10-02