Article | Proceedings of the 58th Conference on Simulation and Modelling (SIMS 58) Reykjavik, Iceland, September 25th ‚Äď 27th, 2017 | The impact of signalling kinetics on controller motif performance
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Title:
The impact of signalling kinetics on controller motif performance
Author:
Geir B. Risvoll: Dept. of Electrical Engineering and Computer Science, University of Stavanger, Norway Tormod Drengstig: Dept. of Electrical Engineering and Computer Science, University of Stavanger, Norway
DOI:
10.3384/ecp17138343
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Full text (pdf)
Year:
2017
Conference:
Proceedings of the 58th Conference on Simulation and Modelling (SIMS 58) Reykjavik, Iceland, September 25th ‚Äď 27th, 2017
Issue:
138
Article no.:
045
Pages:
343-349
No. of pages:
7
Publication type:
Abstract and Fulltext
Published:
2017-09-27
ISBN:
978-91-7685-417-4
Series:
Linköping Electronic Conference Proceedings
ISSN (print):
1650-3686
ISSN (online):
1650-3740
Publisher:
Linköping University Electronic Press, Linköpings universitet


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In this paper we investigate how the disturbance rejection properties of physiological regulatory systems depend on the signalling kinetics between the biochemical species being considered as controlled and manipulated variables. Based on the mathematical model of a physiological regulatory system, we analyse the impact of three different signalling models, i.e. linear signalling, first order and second order Hill kinetics. We separate the analysis in two parts. First we identify to what extend the signalling from the manipulated variable to the controlled variable affect the range and ratio of manageable disturbances. In the second part we investigate whether and how the signalling from the controlled variable to the manipulated variable will affect the parameters of the controller part of the regulatory system. In this context, saturable Hill kinetics display advantages compared to linear signalling.

Keywords: Systems Biology, Control Engineering, Homoeostasis, Signalling Kinetics

Proceedings of the 58th Conference on Simulation and Modelling (SIMS 58) Reykjavik, Iceland, September 25th ‚Äď 27th, 2017

Author:
Geir B. Risvoll, Tormod Drengstig
Title:
The impact of signalling kinetics on controller motif performance
DOI:
http://dx.doi.org/10.3384/ecp17138343
References:
No references available

Proceedings of the 58th Conference on Simulation and Modelling (SIMS 58) Reykjavik, Iceland, September 25th ‚Äď 27th, 2017

Author:
Geir B. Risvoll, Tormod Drengstig
Title:
The impact of signalling kinetics on controller motif performance
DOI:
http://dx.doi.org/10.3384/ecp17138343
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Last updated: 2017-02-21