Article | Proceedings of the 12th International Modelica Conference, Prague, Czech Republic, May 15-17, 2017 | Integrative physiology in Modelica
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Title:
Integrative physiology in Modelica
Author:
Jir√≠ Kofr√°nek: Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Tom√°Ň° Kulh√°nek: Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic MareK Matej√°k: Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Filip JeŇĺek: Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Jan ҆ilar: Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
DOI:
10.3384/ecp17132589
Download:
Full text (pdf)
Year:
2017
Conference:
Proceedings of the 12th International Modelica Conference, Prague, Czech Republic, May 15-17, 2017
Issue:
132
Article no.:
066
Pages:
589-603
No. of pages:
15
Publication type:
Abstract and Fulltext
Published:
2017-07-04
ISBN:
978-91-7685-575-1
Series:
Linköping Electronic Conference Proceedings
ISSN (print):
1650-3686
ISSN (online):
1650-3740
Publisher:
Linköping University Electronic Press, Linköpings universitet


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The integrative model of human physiology connects individual physiological subsystems into a single unit. They are very large (contain thousands of variables) and represent a formalized description of interconnected physiological regulations. The issue of formalization of physiological systems became part of a series of international projects (e.g. the worldwide program "PHYSIOME", or the European program "VIRTUAL PHYSIOLOGICAL HUMAN"). The development of large-scale models of human physiology was facilitated by a new generation (i.e. equation-based) simulation environment, especially by Modelica language. These models can be used to explain the causal relations of the pathogenesis of many diseases, they can be applied in the evaluation of clinical trials and they can also be used in the core of sophisticated medical simulators.

Keywords: Simulation Physiology Integrative models

Proceedings of the 12th International Modelica Conference, Prague, Czech Republic, May 15-17, 2017

Author:
Jir√≠ Kofr√°nek, Tom√°Ň° Kulh√°nek, MareK Matej√°k, Filip JeŇĺek, Jan ҆ilar
Title:
Integrative physiology in Modelica
DOI:
http://dx.doi.org/10.3384/ecp17132589
References:
No references available

Proceedings of the 12th International Modelica Conference, Prague, Czech Republic, May 15-17, 2017

Author:
Jir√≠ Kofr√°nek, Tom√°Ň° Kulh√°nek, MareK Matej√°k, Filip JeŇĺek, Jan ҆ilar
Title:
Integrative physiology in Modelica
DOI:
http://dx.doi.org/10.3384/ecp17132589
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Last updated: 2017-02-21