Article | Proceedings of the 56th Conference on Simulation and Modelling (SIMS 56), October, 7-9, 2015, Linköping University, Sweden | Modeling and Simulation of Triclosan Kinetics and Distribution in Humans Using a PBPK Model
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Title:
Modeling and Simulation of Triclosan Kinetics and Distribution in Humans Using a PBPK Model
Author:
Samee Maharjan: Telemark University College, Norway Roshan Sharma: Telemark University College, Norway Trine Husøy: Dept. of Food, Water and Cosmetics; Norwegian Institute of Public Health (NIPH) Hubert Dirven: Dept. of Food, Water and Cosmetics; Norwegian Institute of Public Health (NIPH) Monica Andreassen: Dept. of Food, Water and Cosmetics; Norwegian Institute of Public Health (NIPH) Bernt Lie: Telemark University College, Norway
DOI:
10.3384/ecp15119279
Download:
Full text (pdf)
Year:
2015
Conference:
Proceedings of the 56th Conference on Simulation and Modelling (SIMS 56), October, 7-9, 2015, Linköping University, Sweden
Issue:
119
Article no.:
028
Pages:
279-288
No. of pages:
10
Publication type:
Abstract and Fulltext
Published:
2015-11-25
ISBN:
978-91-7685-900-1
Series:
Linköping Electronic Conference Proceedings
ISSN (print):
1650-3686
ISSN (online):
1650-3740
Publisher:
Linköping University Electronic Press, Linköpings universitet


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Personal care products (PCPs) such as soaps, perfumes, toothpastes, lotions, etc. contain various chemicals. Triclosan (TCS) is widely used as an antibacterial additive in PCPs. Traces of TCS are found in human plasma and milk indicating absorption through the skin and/or after oral ingestion. In this paper, a Physiologically Based Pharmacokinetic or Toxicokinetic (PBPK/TK) model is developed to assess the behavior of TCS in human body after exposure to PCPs orally or through the skin. The model will describe metabolism, kinetics and distribution in human organs. The developed model is based on available literature data on biotransformation in rodents and humans, and is simulated using MATLAB and/or Modelica. The intention of the work is to further develop the model and fit model parameters to experimental data, and to develop a PBPK model useful for human risk assessment of TCS.

Keywords: Modeling; Simulation; PBPK; Triclosan; Kinetics; Distribution; Humans

Proceedings of the 56th Conference on Simulation and Modelling (SIMS 56), October, 7-9, 2015, Linköping University, Sweden

Author:
Samee Maharjan, Roshan Sharma, Trine Husøy, Hubert Dirven, Monica Andreassen, Bernt Lie
Title:
Modeling and Simulation of Triclosan Kinetics and Distribution in Humans Using a PBPK Model
DOI:
http://dx.doi.org/10.3384/ecp15119279
References:

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Proceedings of the 56th Conference on Simulation and Modelling (SIMS 56), October, 7-9, 2015, Linköping University, Sweden

Author:
Samee Maharjan, Roshan Sharma, Trine Husøy, Hubert Dirven, Monica Andreassen, Bernt Lie
Title:
Modeling and Simulation of Triclosan Kinetics and Distribution in Humans Using a PBPK Model
DOI:
http://dx.doi.org/10.3384/ecp15119279
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