Article | Proceedings of the 11th International Modelica Conference, Versailles, France, September 21-23, 2015 | Modeling Biology in Modelica: The Human Baroreflex
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Title:
Modeling Biology in Modelica: The Human Baroreflex
Author:
Christopher Schölzel: KITE, Technische Hochschule Mittelhessen, Giessen, Germany Alexander Goesmann: Justus Liebig University Giessen, Giessen, Germany Gernot Ernst: Vestre Viken Hospital Trust, Kongsberg, Norway Andreas Dominik: KITE, Technische Hochschule Mittelhessen, Giessen, Germany
DOI:
10.3384/ecp15118367
Download:
Full text (pdf)
Year:
2015
Conference:
Proceedings of the 11th International Modelica Conference, Versailles, France, September 21-23, 2015
Issue:
118
Article no.:
039
Pages:
367-376
No. of pages:
10
Publication type:
Abstract and Fulltext
Published:
2015-09-18
ISBN:
978-91-7685-955-1
Series:
Linköping Electronic Conference Proceedings
ISSN (print):
1650-3686
ISSN (online):
1650-3740
Publisher:
Linköping University Electronic Press, Linköpings universitet


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Systems biology is a field that builds complex multi-scale models of systems that are evolved rather than engineered. No unifying theory exists for biology as it does for engineering domains. Thus, models appear in very diverse forms. Components can be genes, cells, organs or even whole ecosystems. These components can intuitively be represented as classes in an object-oriented language, making systems biology a perfect application for Modelica. However, we still only see very few models from this domain. In an attempt to change this, we show that Modelica can exactly reproduce the simulation results of a reference implementation of an established biological model of the human baroreflex. Our implementation highlights the strengths of Modelica like the event finding mechanism, which makes the model more precise. We also show that biological systems pose interesting challenges like signals with non-uniform delays and the interaction of complex rhythms.

Keywords: systems biology; baroreflex; cardiovascular system; heart rate variability

Proceedings of the 11th International Modelica Conference, Versailles, France, September 21-23, 2015

Author:
Christopher Schölzel, Alexander Goesmann, Gernot Ernst, Andreas Dominik
Title:
Modeling Biology in Modelica: The Human Baroreflex
DOI:
http://dx.doi.org/10.3384/ecp15118367
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Proceedings of the 11th International Modelica Conference, Versailles, France, September 21-23, 2015

Author:
Christopher Schölzel, Alexander Goesmann, Gernot Ernst, Andreas Dominik
Title:
Modeling Biology in Modelica: The Human Baroreflex
DOI:
http://dx.doi.org/10.3384/ecp15118367
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