Article | The 48th Scandinavian Conference on Simulation and Modeling (SIMS 2007); 30-31 October; 2007; Göteborg (Särö) | Intelligent Modelling of a Fluidised bed Granulator Used in Production of Pharmaceuticals

Title:
Intelligent Modelling of a Fluidised bed Granulator Used in Production of Pharmaceuticals
Author:
Esko K. Juuso: Control Engineering Laboratory, Department of Process and Environmental Engineering, University of Oulu
Download:
Full text (pdf)
Year:
2007
Conference:
The 48th Scandinavian Conference on Simulation and Modeling (SIMS 2007); 30-31 October; 2007; Göteborg (Särö)
Issue:
027
Article no.:
012
Pages:
101-108
No. of pages:
8
Publication type:
Abstract and Fulltext
Published:
2007-12-21
Series:
Linköping Electronic Conference Proceedings
ISSN (print):
1650-3686
ISSN (online):
1650-3740
Publisher:
Linköping University Electronic Press; Linköpings universitet


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The aim of dynamic modelling and simulation is to improve the control of the fluidised bed granulator. Modelling and simulation was done on the basis of data collected from several test campaigns. Several modelling methodologies have been compared in Matlab-Simulink environment. A solution based on dynamic linguistic equation models was chosen. The main input variables are humidity difference between incoming and outgoing air; temperature difference between inflowing air and granule and the rate of inflowing air. The final output is the estimated granule size but the overall models contains also dynamic models for temperature and humidity. The simulator combines several models which are specific to the operating conditions. According to the results; the spraying and drying processes included short-duration periods. Extension to fuzzy LE models provides useful information about uncertainties of the forecasted granulation results. The complexity of the models is increased only slightly with the new system based on the extension principle and fuzzy interval analysis.

Keywords: Fluidised bed granulator; linguistic equations; dynamic modelling; fuzzy set systems

The 48th Scandinavian Conference on Simulation and Modeling (SIMS 2007); 30-31 October; 2007; Göteborg (Särö)

Author:
Esko K. Juuso
Title:
Intelligent Modelling of a Fluidised bed Granulator Used in Production of Pharmaceuticals
References:

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The 48th Scandinavian Conference on Simulation and Modeling (SIMS 2007); 30-31 October; 2007; Göteborg (Särö)

Author:
Esko K. Juuso
Title:
Intelligent Modelling of a Fluidised bed Granulator Used in Production of Pharmaceuticals
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