Publications for Ingemar Kvarnström
Co-author map based on ISI articles 2007-

Keywords

x-ray thrombin synthesized synthesis series protease promising potent position plasmepsin p2 p1 inhibitors inhibitor incorporating hiv-1 crystal compounds bace-1 acid

Journal Articles

Veronica Sandgren, Marcus Bäck, Ingemar Kvarnström and Anders Dahlgren
  Design and synthesis of hydroxyethylene-based BACE-1 inhibitors incorporating extended P1 substituents
  Open Medicinal Chemistry Journal, 2013, 7, 1-15.
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Veronica Sandgren, Tatiana Agback, Per-Ola Johansson, Jimmy Lindberg, Ingemar Kvarnström, Bertil Samuelsson, Oscar Belda and Anders Dahlgren
  Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes
  Bioorganic & Medicinal Chemistry, 2012, 29(14), 4377-4389.
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 Web of Science® Times Cited: 3

Fredrik Wångsell, Karin Gustafsson, Ingemar Kvarnström, Neera Borkakoti, Michael Edlund, Katarina Jansson, Jimmy Lindberg, Anders Hallberg, Åsa Rosenquist and Bertil Samuelsson
  Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core
  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45(3), 870-882.
 Web of Science® Times Cited: 11

Marcus Bäck, Jonas Nyhlén, Ingemar Kvarnström, Sara Appelgren, Neera Borkakoti, Katarina Jansson, Jimmy Lindberg, Susanne Nyström, Anders Hallberg, Åsa Rosenquist and Bertil Samuelsson
  Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues.
  Bioorganic & medicinal chemistry, 2008, 16(21), 9471-9486.
 Web of Science® Times Cited: 20

Fredrik Thorstensson, Fredrik Wångsell, Ingemar Kvarnström, Lotta Vrang, Elizabeth Hamelink, Anders Hallberg, Åsa Rosenquist and Bertil Samuelsson
  Synthesis of Novel Potent Hepatitis C Virus NS3 Protease Inhibitors: Discovery of 4-Hydroxy-cyclopent-2-ene-1,2-dicarboxylic Acid as a N-Acyl-L-Hydroxyproline Bioisostere
  Bioorganic & medicinal chemistry, 2007, 15(2), 827-838.
 Web of Science® Times Cited: 6

Marcus Bäck, Per-Ola Johansson, Fredrik Wångsell, Fredrik Thorstensson, Ingemar Kvarnström, Susana Ayesa, Horst Wähling, Mikael Pelcman, Katarina Jansson, Stefan Lindström, Hans Wallberg, Björn Classon, Christina Rydergård, Lotta Vrang, Elizabeth Hamelink, Anders Hallberg, Åsa Rosenquist and Bertil Samuelsson
  Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: use of cyclopentane and cyclopentene P2-motifs.
  Bioorganic & Medicinal Chemistry, 2007, 15(22), 7184-7202.
 Web of Science® Times Cited: 16

Per-Ola Johansson, Marcus Bäck, Ingemar Kvarnström, Katarina Jansson, Lotta Vrang, Elizabeth Hamelink, Anders Hallberg, Åsa Rosenqvist and Bertil Samuelsson
  Potent inhibitors of the hepatitis C virus NS3 protease: use of a novel P2 cyclopentane-derived template
  Bioorganic & Medicinal Chemistry, 2006, 14(15), 5136-5151.
 Web of Science® Times Cited: 17

Per-Ola Johansson, Jimmy Lindberg, Michael J. Blackman, Ingemar Kvarnström, Lotta Vrang, Elizabeth Hamelink, Anders Hallberg, Åsa Rosenquist and Bertil Samuelsson
  Design and synthesis of potent inhibitors of plasmepsin I and II: x-ray crystal structure of inhibitor in complex with plasmepsin II
  Journal of Medicinal Chemistry, 2005, 48(13), 4400-4409.
 Web of Science® Times Cited: 18

Per-Ola Johansson, Yantao Chen, Anna Karin Belfrage, Michael J. Blackman, Ingemar Kvarnström, Katarina Jansson, Lotta Vrang, Elizabeth Hamelink, Anders Hallberg, Åsa Rosenquist and Bertil Samuelsson
  Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II: use of solid-phase synthesis to explore novel statine motifs
  Journal of Medicinal Chemistry, 2004, 47(13), 3353-3366.

J. Lindberg, D. Pyring, S. Lowgren, A. Rosenquist, G. Zuccarello, Ingemar Kvarnström, H. Zhang, L. Vrang, B. Classon, A. Hallberg, B. Samuelsson and T. Unge
  Symmetric fluoro-substituted diol-based HIV protease inhibitors: Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy
  European Journal of Biochemistry, 2004, 271(22), 4594-4602.
 Web of Science® Times Cited: 5

Per-Ola Johansson, Yantao Chen, Anna Karin Belfrage, Michael J. Blackman, Ingemar Kvarnström, Katarina Jansson, Lotta Vrang, Elizabeth Hamelink, Anders Hallberg, Åsa Rosenqvist and Bertil Samuelsson
  Design and Synthesis of Potent Inhibitors of the Malaria Aspartyl Proteases
  Journal of medicinal chemistry., 2004, 47, 3353-3366.
 Web of Science® Times Cited: 36

H.O. Andersson, K. Fridborg, S. Lowgren, M. Alterman, A. Muhlman, M. Bjorsne, N. Garg, Ingemar Kvarnström, W. Schaal, B. Classon, A. Karlen, U.H. Danielsson, G. Ahlsen, U. Nillroth, L. Vrang, B. Oberg, B. Samuelsson, A. Hallberg and T. Unge
  Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors
  European Journal of Biochemistry, 2003, 270(8), 1746-1758.
 Web of Science® Times Cited: 19

Anders Dahlgren, Ingemar Kvarnström, L. Vrang, E. Hamelink, A. Hallberg, A. Rosenquist and B. Samuelsson
  Solid-phase library synthesis of reversed-statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II
  Bioorganic & Medicinal Chemistry, 2003, 11(6), 827-841.
 Web of Science® Times Cited: 19

Anders Dahlgren, Ingemar Kvarnström, L. Vrang, E. Hamelink, A. Hallberg, A. Rosenquist and B. Samuelsson
  New inhibitors of the malaria aspartyl proteases plasmepsin I and II
  Bioorganic & Medicinal Chemistry, 2003, 11(16), 3423-3437.
 Web of Science® Times Cited: 17

Fredrik Thorstensson, Ingemar Kvarnström, Djordje Musil, Ingemar Nilsson and Bertil Samuelsson
  Synthesis of Novel Thrombin Inhibitors. Use of Ring-Closing Metathesis Reactions for Synthesis of P2 Cyclopentene and Cyclohexene Dicarboxylic Acid Derivatives
  Journal of Medicinal Chemistry, 2003, 46(7), 1165-1179.
 Web of Science® Times Cited: 19

Anders Dahlgren, J. Branalt, Ingemar Kvarnström, I. Nilsson, D. Musil and B. Samuelsson
  Synthesis of potential thrombin inhibitors. Incorporation of tartaric acid templates as P2 proline mimetics
  Bioorganic & Medicinal Chemistry, 2002, 10(5), 1567-1580.
 Web of Science® Times Cited: 9

Anders Dahlgren, Per-Ola Johansson, Ingemar Kvarnström, Djordje Musil, Ingemar Nilsson and Bertil Samuelsson
  Novel morpholinone-based D-Phe-Pro-Arg mimics as potential thrombin inhibitors: design, synthesis, and X-ray crystal structure of an enzyme inhibitor complex
  Bioorganic & Medicinal Chemistry, 2002, 10(6), 1829-1839.
 Web of Science® Times Cited: 16

David Pyring, Jimmy Lindberg, Åsa Rosenquist, Guido Zuccarello, Ingemar Kvarnström, Hong Zhang, Lotta Vrang, Torsten Unge, Björn Classon, Anders Hallberg and Bertil Samuelsson
  Design and Synthesis of Potent C2-Symmetric Diol-Based HIV-1 Protease
  Journal of medicinal chemistry., 2001, 44, 3083-3091.
 Web of Science® Times Cited: 24

Jonas W. Nilsson, Fredrik Thorstensson, Ingemar Kvarnström, Tudor Oprea, Bertil Samuelsson and Ingemar Nilsson
  Solid-phase synthesis of libraries generated from a 4-phenyl-2-carboxy-piperazine Scaffold
  Journal of Combinatorial Chemistry, 2001, 3(6), 546-553.
 Web of Science® Times Cited: 18

Jonas W. Nilsson, Ingemar Kvarnström, Djordje Musil, Ingemar Nilsson and Bertil Samuelsson
  Synthesis and SAR of Thrombin Inhibitors Incorporating a Novel 4-Amino-Morpholinone Scaffold: Analysis of X-ray Crystal Structure of Enzyme Inhibitor Complex
  Journal of Medicinal Chemistry, 2001, 46(19), 3985-4001.
 Web of Science® Times Cited: 20

D Noteberg, J Branalt, Ingemar Kvarnström, M Linschoten, D Musil, JE Nystrom, G Zuccarello and B Samuelsson
  New proline mimetics: Synthesis of thrombin inhibitors incorporating cyclopentane- and cyclopentenedicarboxylic acid templates in the P2 position. Binding conformation investigated by X-ray crystallography
  Journal of Medicinal Chemistry, 2000, 43(9), 1705-1713.
 Web of Science® Times Cited: 24

K Oscarsson, B Classon, Ingemar Kvarnström, A Hallberg and B Samuelsson
  Solid phase assisted synthesis of HIV-1 protease inhibitors. Expedient entry to unsymmetrical substitution of a C-2 symmetric template
  Canadian journal of chemistry (Print), 2000, 78(6), 829-837.
 Web of Science® Times Cited: 9

J. Wachtmeister, A. Muhlman, B. Classon, Ingemar Kvarnström, A. Hallberg and B. Samuelsson
  Impact of the central hydroxyl groups on the activity of symmetrical HIV-1 protease inhibitors derived from L-mannaric acid
  Tetrahedron, 2000, 56(20), 3219-3225.
 Web of Science® Times Cited: 11

Daniel Nötberg, Jonas Brånalt, Ingemar Kvarnström, Marcel Linschoten, Djordje Musil, Jan-Erik Nyström, Guido Zuccarello and Bertil Samuelsson
  New Proline Mimetics: Synthesis of Thrombin Inhibitors Incorporating
  Journal of medicinal chemistry., 2000, 43, 1705-1713.

Ph.D. Theses

Veronica Sandgren
  Design and Synthesis of Inhibitors Targeting BACE-1, an Aspartic Protease Involved in the Pathogenesis of Alzheimer’s Disease
  2012.


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Marcus Bäck
  Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Serine Protease and the Aspartic Protease BACE-1
  2009.


  Fulltext PDF

Fredrik Thorstensson
  Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library
  2005.


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Jonas Nilsson
  Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule: Peptide Conjugates as Protein Actors
  2005.


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Licentiate Theses

Fredrik Wångsell
  Design and Synthesis of Serine and Aspartic Protease Inhibitors
  2006.


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